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KMID : 0377519870120030339
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Chung-Ang Journal of Medicine
1987 Volume.12 No. 3 p.339 ~ p.346
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Effects of Vanadate on the Depolarized Myocardium
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Abstract
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Effects of vanadate on the isometric contraction, membrane potential and its maximal rate` of depolarization of rabbit ventricular papillary muscles were recorded in normal Tyrode solution and 19 mM ´K+-Tyrode solution.
Following results were obtained:
1. Vanadate increased the isometric contractions in normal Tyrode and 19 mM K+-Tyrode solution in a dose-dependent manner.
2. Vanadate increased the duration and Vmax of slow action potential.
3. Vanadate induced slight hyperpolarization of unstimulated quiet preparations in normal and high K+-Tyrode solution.
4. Effects of vanadate which were observed in K+-depolarized preparations were reversed by diltiazem, a calcium channel blocker.
It could be concluded that vanadate has positive inotropic effect by increasing Ca-current in the papillary muscle of the rabbit.
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